hayaspeed prep
Glycolysis sheet
10-mark answer frame

Describe glycolysis with its energetics.

How to lay out the answer. Follow the frame, then write it in your own words.

  1. 1 · Open in two lines. Glycolysis (Embden–Meyerhof pathway) breaks one glucose into two pyruvate in the cytoplasm of all cells, with or without oxygen.
  2. 2 · Draw the pathway. [Diagram: glucose to pyruvate, all 10 enzymes labelled, ATP and NADH marked]
  3. 3 · Write the 10 steps in two phases.
    • Preparatory phase (steps 1–5): two ATP spent, glucose split into two 3-carbon sugars.
    • Payoff phase (steps 6–10): NADH and ATP made, twice per glucose.
  4. 4 · Energy count. −2 ATP (steps 1, 3), +4 ATP (steps 7, 10 twice) = net 2 ATP and 2 NADH.
  5. 5 · Regulation. Hexokinase, PFK-1 and pyruvate kinase are irreversible and control the rate. PFK-1 is rate-limiting.
  6. 6 · Significance. Only energy source for red blood cells. Works without oxygen (lactate). Provides intermediates for other pathways.
  7. 7 · Nutrition link. NAD+ comes from niacin (B3); kinases need magnesium.
  8. 8 · Close in one line. Sum up glycolysis as the first, universal stage of glucose breakdown.

Scoring tip: A clean diagram and the enzyme names carry most of the marks. Neat labels beat long paragraphs.

Write-up practice

The check looks for key words only. It does not grade your answer and never writes it for you.